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4-PDS

Item # Unit Size
P017-10
1 g

For Research Use Only Products

MSDS

Chemical Name: 4,4'-Dithiodipyridine
CAS:
2645-22-9


Appearance: white or pale yellow powder
Molar absorptivity: ≥14,000 at 235 nm
MW:
220.32, C10H8N2S2

Storage Condition : ambient temperature
Shipping Condition: ambient temperature

Product Description
2-PDS and 4-PDS are used for the photometric determination of thiol groups in biological samples. These compounds react with the thiol groups at pH 5 to form mercaptopyridine (Fig. 1 and 2). The maximum wavelengths of 2-Mercaptopyridine and 4-Mercaptopyridine are 343 nm and 324 nm, respectively.


Fig 1. 4-PDS reaction with thiol compound



References
1. D. R. Grassetti, et al., Determination of Sulfhydryl Groups with 2, 2’- or 4, 4’-Dithiodipyridine. Arch Biochem Biophys. 1967;119:41-49.
2. R. E. Humphrey, et al., Spectrophotometric Determination of Sulfite with 4, 4’-Dithiodipyridine and 5, 5’-Dithiobis-(2-nitrobenzoic acid). Anal Chem. 1970;42:698-702.
3. R. E. Humphrey, et al., Spectrophotometric Determination of Cyanide with Organic Disulphides. Talanta. 1971;18:491-497.
4. T. Uete, et al., Spectrophotometric Micromethod for Measuring Cholinesterase Activity in Serum or Plasma. Clin Chem. 1972;18:454-458.