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Ins(1,4,5)P3 (synthetic)

Item # Unit Size
I007-10
100 µg
I007-12
1 mg

For Research Use Only Products

MSDS
Chemical Name: D-myo-Inositol-1,4,5-triphosphate, tripotassium salt
CAS: 85166-31-0 (free base)


Appearance:
White pellet
Purity: pass test (TLC)
MW: 534.37, C6H12K3O15P3

Storage Condition: -20ºC, protect from light
Shipping Condition: ambient temperature

Product Description
Inositol phosphates and diacylglycerols are generated from phosphatidyl inositols by phospholipase C. They are involved in cellular calcium ion movements as second messengers. Inositol-1,4,5-triphosphate(Ins(1,4,5)P3) is an extremely important messenger that triggers calcium ion release from endoplasmic and sarcoplasmic reticulum. It is thought to increase the calcium sensitivity of the inositol- induced calcium release(IICR) channel in the intracellular calcium source. Thus, the IICR channel can be opened with a low level of calcium ion concentration, causing a dramatic calcium burst into the cytosol. The released calcium ions and diacylglycerol then activate protein kinase C, which is one of the key enzymes in signal transduction.

Chemical Structure


References
1. M. Hirata, et al., Synthetic Inositol Trisphosphate Analogs and Their Effects on Phosphatase, Kinase, and the Release of Ca2+. J Biol Chem. 1989;264:20303-20308.