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-SulfoBiotics- GYY4137

Item # Unit Size
10 mg

For Research Use Only Products

Storage Condition : 0-5
Shipping Condition : ambient temperature
Purity : ≥95.0%
Chemical name: (4-Methoxyphenyl)morpholinylphosphinodithioic acid, morpholine salt
M.W.: 376.47 
CAS#: 106740-09-4

Product Description:

GYY4137 is one of the synthetic hydrogen sulfide donors derived from Lawsson’s reagent. It is water-soluble and releases H2S very slowly by hydrolysis in aqueous solutions. GYY4137 has shown distinct cellular effects such as anti-hypertensive, anti-atherosclerotic and anti-tumor activities in several reports.

        Fig. 1 H2S Releasing Mechanism of GYY4137s



       Fig. 2 H2S Releasing Curve of GYY4137 in PBS

H2S donors:

  1. L. Li, M. Whiteman, Y. Y. Guan, K. L. Neo, Y. Cheng, S. W. Lee, Y. Zhao, R. Baskar, C- H. Tang and P. K. Moore,Circulation, 2008, 117, 2351.
  2. Z. Liu, Y. Han, L. Li, H. Li, G. Meng, X. Li, M. Shirhan, M. T. Peh, L. Xie, S. Zhou, X. Wang, Q. Chen, W. Dai,C-H. Tang, S. Pan, P.K. Moore, and Y. Ji, Br J Pharmacol.,2013, 169, 1795.
  3. Z. W. Lee, J. Zhou, C-S Chen, Y. Zhao, C-H. Tan, L Li, P. K. Moore and L-W. Deng, PLoS One., 201 1, 6, e21077.