Storage Condition : 0-5℃
Shipping Condition : ambient temperature
Purity : ≥95.0%
Chemical name: N-Butyl-N2-acetyl-S-pivaloylsulfanyl-DL-penicillamine amide
Thiol-activated hydrogen sulfide donor 8 ℓ and 8оprepared from penicillamine release H2S upon reaction with
reducing agents containing sulfhydryl groups such as cysteine and reduced glutathione in a similar manner
to 5 a. The H2S releasing rates depend on concentrations of thiols, and donor 8о gives a slower H2S
releasing rate than donor 8 ℓ. These donors are useful to investigate the effects of H2S releasing rates on
cellular functions. *H2S donor 8ℓ and 8o were developed by Dr. Ming Xian of Washington State University.
Fig. H2S Releasing Curves of Donor 8l and 8o in PBS
- Y. Zhao, S. Bhushan, C. Yang, H. Otsuka, J. D. Stein, A. Pacheco, B. Peng, N. O. Devarie-Baez, H. C. Aguilar , D. J.Lefer, and M. Xian, Chem. Biol., 2013, 8, 1283.