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Item #: SB17 -
Product Description Biotin-HPDP(WS) is a novel water-soluble biotin-labeling reagent that is modified from Biotin-HPDP (Product code: B573). Biotin-HPDP is a conventional reagent to introduce a biotin moiety to a sulfhydryl group of protein via reversible disulfide bond. This reagent is useful for affinity-purification of biotinylated proteins by using avidin-coated beads, because the disulfide bond is cleavable by a reducing agent (Fig.1). Thus, Biotin-HPDP has been widely used for biotin...
Item #: SB21 -
Product Description: It has been recognized that hydrogen sulfide (H2S) has an important role as a physiological active substance for vasodilation, cytoprotection, and modulation of insulin secretion. H2S is considered as a gaseous molecule such as nitric oxide and carbon monoxide. However, around 80% of the total sulfide exists as hydrogen sulfide anion (HS- ) under physiological condition, since the pKa is about 7. In addition, HS- easily converts to various biochemical molecules such as...
Item #: SB22 -
Product Description: It has been recognized that hydrogen sulfide (H2S) has an important role as a physiological active substance for vasodilation, cytoprotection, and modulation of insulin secretion. H2S is considered as a gaseous molecule such as nitric oxide and carbon monoxide. However, around 80% of the total sulfide exists as hydrogen sulfide anion (HS- ) under physiological condition, since the pKa is about 7. In addition, HS- easily converts to various biochemical molecules such as...
Item #: SB20 -
Product Description Modification of protein thiols is one of the most important post-translational modifications and it occurs according to the redox states in cells. It has recently been revealed that the modifications of thiol groups control cellular functions such as transcription, protein expression, cell death, etc. Therefore, detection of the redox states of the individual protein is important to understand cellular events. -SulfoBiotics- PEG-PCMal is a reagent to visualize the redox...
Item #: SB12 -
Product Description: Protein thiol is a major redox signaling in the cellular processes. Modification of protein thiol by oxidative stress associate with the redox state in the cells. The approach of this kit is detecting the number of thiol residues accurately in order to study the redox state in oxidative stress environment. Fig. 1 Redox States of Thiol group(s) in Protein Mechanism of Thiol Modification with Protein-SHifter: Fig. 2 Maleimido group of the Protein-SHifter binds to a free...
Item #: SB10 -
Product Description It becomes obvious that there are a lots of molecules containing sulfane sulfurs such as persulfides and polysulfides in living organism. These molecular species are involved in production, storage and release of hydrogen sulfide, which is recognized as an important physiological mediator. Furthermore, recent studies reveal that persulfides and polysulfides may control intracellular signal transduction through s-sulfhydration of proteins. SSP4 (Sulfane Sulfur Probe 4) is a...