Mitochondria Research

Product Description MitoRed is a cell-membrane-permeable, rhodamine-based dye. It localizes in mitochondria and emits red fluorescence (Fig. 1). The interaction of MitoRed with mitochondria depends on the membrane potential of the mitochondria. Mitochondria can be stained with 20 to 200 nM MitoRed. The excitation and emission wavelengths of MitoRed are 560 nm and 580 nm, respectively. Fig. 1 Cell staining mechanism ...

Product Description Rhodamine 123 (Rh123) is cell-membrane permeable and localizes in mitochondria of viable cells to emit yellowish-green fluorescence (Fig. 1). Rh123 is utilized for staining a wide variety of cells, including plant cells and bacteria. Since there is a correlation between the amount of ATP in a cell and the fluorescence intensity of Rh123, this compound is used for the detection of intracellular ATP. Rh123 is also used in cancer research. Fig. 1 Cell staining mechanism ...

Mitochondria synthesize ATP using oxygen to produce necessary energy for living cells. Lowering of mitochondrial activity and dysfunction are known to be closely related to cancer, aging, and neurodegenerative diseases such as Alzheimer’s and Parkinson’s diseases. Mitochondrial membrane potential is a parameter used to measure with mitochondrial condition. How is the membrane potential detected? JC-1 forms aggregate (in healthy mitochondria) with red fluorescence.As membrane potential...

Product Description It is reported that iron is the most abundant transition metal element within an organism and shows various physiological activities. Recently, free iron in living cells is getting attention because its high reactivity is suggested to be related to cellular damage or death. Free iron exists in its stable redox states, ferrous ion (Fe2+) and ferric ion (Fe3+). In living cells, it is considered that understanding the behavior of Fe2+ is more important than that of Fe3+...

Product DescriptionA mitochondrion is a multifunctional organelle not only involved in energy production in a cell, but other additional cellular functions. The active cycle of mitochondrial fusion and division induces morphological changes, which is called mitochondrial dynamics. Abnormalities in morphological control of mitochondria are associated with neurodegenerative diseases, metabolic disorders, aging, and so on. Therefore, the demand for long-term observation of mitochondrial dynamics...

Product Description A mitochondrion is a multifunctional organelle not only involved in energy production in a cell, but other additional cellular functions. The active cycle of mitochondrial fusion and division induces morphological changes, which is called mitochondrial dynamics. Abnormalities in morphological control of mitochondria are associated with neurodegenerative diseases, metabolic disorders, aging, and so on. Therefore, the demand for long-term observation of mitochondrial dynamics...

Product Description A mitochondrion is a multifunctional organelle not only involved in energy production in a cell, but other additional cellular functions. The active cycle of mitochondrial fusion and division induces morphological changes, which is called mitochondrial dynamics. Abnormalities in morphological control of mitochondria are associated with neurodegenerative diseases, metabolic disorders, aging, and so on. Therefore, the demand for long-term observation of mitochondrial dynamics...

Product Description Mitochondria play crucial roles in energy metabolism and also other cellular functions (e.g., apoptosis, and biosynthesis of heme, amino acids, and phospholipids). Mitochondria have two double-membrane structures the inner and outer membranes which differ with respect to their shape and properties. In particular, the mitochondrial inner membrane forms cristae (a folded structure) to enable effective oxidative phosphorylation. Transmission electron microscopy (TEM) has...

Mitophagy Detection Kit Mtphagy Dye Product Description Simple Procedure : Just Add Mtphagy Dye Comparison with Autophagy Marker Mitophagy Detection in Starved Cells Experimental Example: Induction of Mitophagy by CCCP Mitophagy Induction and Detection of Mitochondrial Membrane Potential Changes Product Description Mitophagy Detection Kit is optimized for mammalian cells. Mitochondria is one of the cytoplasmic organelle that plays a crucial role in cells such as production of energy for cell...

Product Description Mitochondria is an important organelle that uses oxygen to synthesize ATP, producing the necessary energy for living cells to thrive1). Decreased mitochondrial activity and mitochondrial dysfunction are associated with cancer, aging, and neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease2,3). Therefore, mitochondrial membrane potential (MMP) has been widely studied as a promising target for mitochondria-related diseases. Reference1) K. F. Ferri, et al.,...