Isothiocyanobenzyl-EDTA
Chelate Labeling Reagent
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Product codeM030 Isothiocyanobenzyl-EDTA
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CAS No.105394-74-9
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Chemical name1-(4-IsothiOcyanatobenzyl)ethylenediamine-N,N,N',N'-tetraacetic acid
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MWC18H21N3O8S=439.44
| Unit size | Price | Item Code |
|---|---|---|
| 10 mg | M030-10 |
Product Description of Amine-Reactive Biotins
Isothiocyanobenzyl-EDTA adds EDTA moieties to proteins through their amine groups. The EDTA-tagged protein can then be labeled with heavy metal ions and radioactive metals, such as 111In and 99Tc, and used for immunoimaging.
Chemical Structure
Technical info
References
1) C. F. Meares and T. G. Wensel, "Metal Chelates as Probes of Biological Systems", Acc. Chem. Res., 1984, 17, 202.
2) S. V. Deshpande, R. Subramanian, M. J. McCall, S. J. Denardo, G. L. Denardo and C. F. Meares, "Metabolism of Indium Chelates Attached to Monoclonal Antibody: Minimal Transchelation of Indium form Benzyl-EDTA Chelate in vivo", J. Nucl. Med., 1990, 31, 218.
3) S. Mirzadeh, M. W. Brechbiel, R. W. Atcher and O. A. Gansow, "Radiometal Labeling of Immunoproteins: Covalent Linkage of 2-(4-Isothiocyanatobenzyl)diethylenetriaminepentaacetic acid Ligands to Immunoglobulin", Bioconjugate Chem., 1990, 1, 59.
Handling and storage condition
| Appearance： | White to slightly yellowish brown powder |
|---|---|
| Purity (HPLC)： | ≧ 90.0 % |
| IR spectrum： | Authentic |
| -20°C, Protect from moisture |
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