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Isothiocyanobenzyl-EDTA

Item # Unit Size
M030-10
10 mg

For Research Use Only Products

Chemical Name: 1-(4-Isothiocyanatobenzyl)ethylenediamine-N,N,N EN Etetraacetic acid
CAS: 105394-74-9

Appearance: White to slightly yellowish-brown powder
Purity: ≥90.0% (HPLC)
MW: 439.44, C18H21N3O8S

Storage Condition: -20oC
Shipping Condition: ambient temperature
MSDS

Product Description of Amine-Reactive Biotins
Isothiocyanobenzyl-EDTA adds EDTA moieties to proteins through their amine groups. The EDTA-tagged protein can then be labeled with heavy metal ions and radioactive metals, such as 111In and 99Tc, and used for immunoimaging.

Chemical Structure


<Caution>
When it is difficult to take out all the powder from the container,
please add the solvent into a container and dissolve it before its use.
1) C. F. Meares and T. G. Wensel, "Metal Chelates as Probes of Biological Systems", Acc. Chem. Res., 198417, 202.
2) S. V. Deshpande, R. Subramanian, M. J. McCall, S. J. Denardo, G. L. Denardo and C. F. Meares, "Metabolism of Indium Chelates Attached to Monoclonal Antibody: Minimal Transchelation of Indium form Benzyl-EDTA Chelate in vivo", J. Nucl. Med.199031, 218.
3) S. Mirzadeh, M. W. Brechbiel, R. W. Atcher and O. A. Gansow, "Radiometal Labeling of Immunoproteins: Covalent Linkage of 2-(4-Isothiocyanatobenzyl)diethylenetriaminepentaacetic acid Ligands to Immunoglobulin", Bioconjugate Chem.19901, 59.