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Item # Unit Size
100 mg

For Research Use Only Products

Chemical Name: N-Succinimidyl 3-(2-pyridyldithio)propionate
CAS: 68181-17-9

Appearance: Amine and sulfhydryl group cross-linking
Purity: ≥98.0% (HPLC)
MW: 312.37, C12H12N2O4S2

Storage Condition: 0-5ºC,
Shipping Condition: ambient temperature

Product Description
SPDP, a hetero-bifunctional reagent, is useful for bridging two different proteins, such as enzymes and antibodies. SPDP first reacts with a protein molecule through its amino groups. SPDP introduces a pyridyl disulfide moiety to the protein, which is then reduced by DTT to form thiol groups. These thiol groups then form a disulfide bond with another protein molecule thus yielding a heterodimer protein.

Structural Formula

Homo-bifunctional Reagents
Product Name Code Length (Å) Solvent
SPDP S291 4.1 Acetonitrile
1) P. Walden, Z. A. Nagy and J. Klein, Major Histocompatibility Complex-Restricted and Unrestricted Activation of Helper T Cell Lines by Liposome-bound Antigens, J. Mol. Cell. Immunol, 1986, 2, 191.
2) R. D. Gordon, W. E. Fieles, D. L. Schotland, R. Hogue-Angeletti and R. L. Barchi, Topographical Localization of the C-terminal Region of the Voltagedependent Sodium Channel from Electrophorus Electricus Using Antibodies Raised Against a Synthetic Peptide, Proc. Natl. Acad. Sci. USA, 1987,84, 308.