Carboxylic acid-SAM Formation reagent

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Carboxylic acid-SAM Formation reagent

Item #	Unit Size
C488-10	1 µmol x 3

For Research Use Only Products

Easily forms carboxy-terminated monolayers on gold

Suppress non-specific binding

Appearance: Colorless or pale yellow liquid

Description
Application

Keyword: SAM, Self-Assembled Monolayers
             SPR (Surface Plasmon Resonance)
             QCM (Quartz Crystal Microbalance)
             biosensors, protein immobilization

Product Description

Carboxylic acid-SAM Formation Reagent is used to prepare carboxylic acid- terminated self-assembled monolayers (SAMs) on gold surfaces as biosensors detected by QCM (Quartz Crystal Microbalance), SPR (Surface Plasmon Resonance), and electrochemical analysis. Coupled with carboxyl group activation method using NHS/WSC, carboxylic acid-SAM can be used as an interface to immobilize proteins or peptides and other ligands on gold surfaces (Fig. 1). In general, carboxylic acid-SAM provides some non-specific binding because of its negative charge. However, surfaces prepared using -carboxylic acid-SAM Formation Reagent presents less non-specific binding than thiose commonly prepared with carboxylic acid-SAM (Fig. 2).

Fig. 1 A biosensor construction by Carboxylic acid-SAM Formation Reagent

Fig. 2 Comparison of non-specific binding between carboxylic acid-SAM prepared with carboxylic acid-SAM Formation Reagent and commonly prepared SAM

Example of Solvents
1 mmol/L (ethanol solution)：Dissolve 1 bottle in 1 mL ethanol

Published Paper:

An angular fluidic channel for prism-free surface-plasmon-assisted fluorescence capturing
K Nomura, SCB Gopinath, T Lakshmipriya, et. al, Nature, 2013,