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Carboxylic acid-SAM Formation reagent

Item # Unit Size
C488-10
1 µmol x 3

For Research Use Only Products

  • Easily forms carboxy-terminated monolayers on gold
  • Suppress non-specific binding
  •  Appearance: Colorless or pale yellow liquid



    Keyword: SAM, Self-Assembled Monolayers
                 SPR (Surface Plasmon Resonance)
                 QCM (Quartz Crystal Microbalance)
                 biosensors, protein immobilization

    Product Description
    Carboxylic acid-SAM Formation Reagent is used to prepare carboxylic acid- terminated self-assembled monolayers (SAMs) on gold surfaces as biosensors detected by QCM (Quartz Crystal Microbalance), SPR (Surface Plasmon Resonance), and electrochemical analysis. Coupled with carboxyl group activation method using NHS/WSC, carboxylic acid-SAM can be used as an interface to immobilize proteins or peptides and other ligands on gold surfaces (Fig. 1). In general, carboxylic acid-SAM provides some non-specific binding because of its negative charge. However, surfaces prepared using -carboxylic acid-SAM Formation Reagent presents less non-specific binding than thiose commonly prepared with carboxylic acid-SAM (Fig. 2).


    Fig. 1 A biosensor construction by Carboxylic acid-SAM Formation Reagent


    Fig. 2 Comparison of non-specific binding between carboxylic acid-SAM prepared with carboxylic acid-SAM Formation Reagent and commonly prepared SAM
    Example of Solvents
    1 mmol/L (ethanol solution):Dissolve 1 bottle in 1 mL ethanol

    Published Paper:

    An angular fluidic channel for prism-free surface-plasmon-assisted fluorescence capturing
    K Nomura, SCB Gopinath, T Lakshmipriya, et. al, Nature, 2013,