Storage Condition : 0-5℃
Shipping Condition : ambient temperature
Purity : ≥95.0%
Chemical name: N-Butyl-N2-acetyl-S-pivaloylsulfanyl-DL-penicillamine amide
Thiol-activated hydrogen sulfide donor 8 ℓ and 8оprepared from penicillamine release H2S upon reaction with
reducing agents containing sulfhydryl groups such as cysteine and reduced glutathione in a similar manner
to 5 a. The H2S releasing rates depend on concentrations of thiols, and donor 8о gives a slower H2S
releasing rate than donor 8 ℓ. These donors are useful to investigate the effects of H2S releasing rates on
cellular functions. *H2S donor 8ℓ and 8o were developed by Dr. Ming Xian of Washington State University.
Fig. H2S Releasing Curves of Donor 8l and 8o in PBS
1) Y. Zhao, S. Bhushan, C. Yang, H. Otsuka, J. D. Stein, A. Pacheco, B. Peng, N. O. Devarie-Baez, H. C. Aguilar , D. J. Lefer and M. Xian, “Controllable Hydrogen Sulfide Donors and Their Activity against Myocardial Ischemia-Reperfusion Injury”, Chem. Biol., 2013, 8, 1283.
2) Z. W. Lee, J. Zhou, C-S. Chen, Y. Zhao, C-H. Tan, L. Li, P. K. Moore, and L-W. Deng, “The Slow-Releasing Hydrogen Sulfide Donor, GYY4137, Exhibits Novel Anti-Cancer Effects In Vitro and In Vivo”, PLos One, 2011, 6, e21077.