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-SulfoBiotics- H2S donor 8o

Item # Unit Size
SB09-10
10 mg

For Research Use Only Products

Storage Condition : 0-5
Shipping Condition : ambient temperature
Purity : ≥95.0%
Chemical name: N-Butyl-N2-acetyl-S-pivaloylsulfanyl-DL-penicillamine amide
M.W.: 362.55
CAS#: 1430811-12-3



Product Description:

Thiol-activated hydrogen sulfide donor 8 ℓ and 8оprepared from penicillamine release H2S upon reaction with reducing agents containing sulfhydryl groups such as cysteine and reduced glutathione in a similar manner to 5 a. The H2S releasing rates depend on concentrations of thiols, and donor 8о gives a slower H2S releasing rate than donor 8 ℓ. These donors are useful to investigate the effects of H2S releasing rates on cellular functions. *H2S donor 8ℓ and 8o were developed by Dr. Ming Xian of Washington State University.


      



Data:

              

       Fig.  H2S Releasing Curves of Donor 8l and 8o in PBS




1) Y. Zhao, S. Bhushan, C. Yang, H. Otsuka, J. D. Stein, A. Pacheco, B. Peng, N. O. Devarie-Baez, H. C. Aguilar , D. J. Lefer and M. Xian, “Controllable Hydrogen Sulfide Donors and Their Activity against Myocardial Ischemia-Reperfusion Injury”, Chem. Biol., 2013, 8, 1283.
2) Z. W. Lee, J. Zhou, C-S. Chen, Y. Zhao, C-H. Tan, L. Li, P. K. Moore, and L-W. Deng, “The Slow-Releasing Hydrogen Sulfide Donor, GYY4137, Exhibits Novel Anti-Cancer Effects In Vitro and In Vivo”, PLos One, 2011, 6, e21077.